Article

A gene desert required for regulatory control of pleiotropic <i>Shox2</i> expression and embryonic survival

2020-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Gene deserts are defined as genomic regions devoid of protein coding genes and spanning more than 500 kilobases, collectively encompassing about 25% of the human genome. Approximately 30% of all gene deserts are enriched for conserved elements with cis -regulatory signatures. These are located predominantly near developmental transcription factors (TFs) but despite predicted critical functions,...

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Literature Corpus work: f1d6ef82-e09b-5519-8c73-2acc4c68bb8d
DOI: 10.1101/2020.11.22.393173

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