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Article

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development.

Circulation - 10 Apr 2007

Blaschke Rüdiger J, Hahurij Nathan D, Kuijper Sanne, Just Steffen, Wisse Lambertus J, Deissler Kirsten, Maxelon Tina, Anastassiadis Konstantinos, Spitzer Jessica, Hardt Stefan E, Schöler Hans, Feitsma Harma, Rottbauer Wolfgang, Blum Martin, Meijlink Frits, Rappold Gudrun, Gittenberger-de Groot Adriana C

Abstract excerpt

BACKGROUND: Identifying molecular pathways regulating the development of pacemaking and coordinated heartbeat is crucial for a comprehensive mechanistic understanding of arrhythmia-related diseases. Elucidation of these pathways has been complicated mainly by an insufficient definition of the dev...

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Identifiers

PMID: 17372176
DOI: 10.1161/CIRCULATIONAHA.106.637819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17372176-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development.PMID 17372176Read ↗

Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.Semantic proximity Read ↗

Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb.Semantic proximity Read ↗

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.Semantic proximity Read ↗

The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.Semantic proximity Read ↗

Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial FibrillationSemantic proximity Read ↗

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic programSemantic proximity Read ↗

Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.Semantic proximity Read ↗

A gene desert required for regulatory control of pleiotropic <i>Shox2</i> expression and embryonic survivalSemantic proximity Read ↗

<i>Pitx2</i> prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationSemantic proximity Read ↗

Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.Semantic proximity Read ↗

Generation of two homozygous SHOX2 knock-out human induced pluripotent stem cell lines using CRISPR/Cas9.Semantic proximity Read ↗

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.Semantic proximity Read ↗

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