Article

Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Transposable elements (TEs) have extensively reshaped the cis -regulatory landscape of mammalian genomes, yet the mechanisms that govern their context-specific activity remain incompletely understood. KRAB zinc finger proteins (KZFPs), a large family of transcription factors specialized in TE recognition, are known repressors of TE-derived regulatory activity through TRIM28-mediated H3K9me3 dep...

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Literature Corpus work: d8845cc0-20c2-5d98-8e3d-15a02d5c1c00
DOI: 10.1101/2025.05.13.653700

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