Article

A cooperative response to endocardial NOTCH signaling stimulation regulates transcriptional activity during cardiac valve development and disease

2023-03-25

Abstract excerpt

<h4>Background</h4> The endocardium is a crucial signaling center for cardiac valve development and maturation. Genetic analysis has identified several human endocardial genes whose inactivation leads to bicuspid aortic valve (BAV) formation and/or calcific aortic valve disease (CAVD), but knowledge is very limited about the role played in valve development and disease by non-coding endocardial regulatory regions...

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Literature Corpus work: 332c764c-f187-50ca-a765-6ccb9ae51e3b
DOI: 10.1101/2023.03.23.533882

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