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Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor function

21 Feb 2023

Abstract excerpt

Acute anemia elicits broad transcriptional changes in erythroid progenitors and precursors. We previously discovered a cis-regulatory transcriptional enhancer at the sterile alpha motif domain-14 enhancer locus (S14E), defined by a CANNTG-spacer-AGATAA composite motif and occupied by GATA1 and TAL1 transcription factors, is required for survival in severe anemia. However, S14E is only 1 of dozens of...

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PMID: 36809789
DOI: 10.1182/bloodadvances.2022009163

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