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Host-directed therapies targeting the tuberculosis granuloma stroma

1 Mar 2020

Abstract excerpt

Mycobacteria have co-evolved with their hosts resulting in pathogens adept at intracellular survival. Pathogenic mycobacteria actively manipulate infected macrophages to drive granuloma formation while subverting host cell processes to create a permissive niche. Granuloma residency confers phenotypic antimicrobial resistance by physically excluding or neutralising antibiotics. Host-directed therapies (HDTs)...

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PMID: 32149337
DOI: 10.1093/femspd/ftaa015

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