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Differential activation of NF-κB and HIF-1α between alveolar-like macrophages and myeloid-derived macrophages drive inflammatory differences following <i>Mycobacterium abscessus</i> infection

2025-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary infections caused by Mycobacterium abscessus (Mab), a rapidly growing nontuberculous mycobacterium (NTM), are on the rise in patients with chronic or acquired lung disease. In contrast to immunocompetent individuals, these patient cohorts exhibit abnormal pulmonary function that result from chronic inflammation and mucus build-up. Treatment regimens rely on multi-drug cocktails yet Ma...

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Literature Corpus work
3d8de914-a621-5330-a488-56b20b298ad5
DOI
10.1101/2025.04.03.647026
Open publication

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Differential activation of NF-κB and HIF-1α between alveolar-like macrophages and myeloid-derived macrophages drive inflammatory differences following <i>Mycobacterium abscessus</i> infectionDOI 10.1101/2025.04.03.647026
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