Article

<i>In situ</i> cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment

2025-03-25

Abstract excerpt

Defective mitochondrial quality control in response to loss of mitochondrial membrane polarization is implicated in Parkinson’s disease by mutations in PINK1 and PRKN . Application of in situ cryo-electron tomography (cryo-ET) made it possible to visualize the consequences of mitochondrial depolarization at higher resolution than heretofore attainable. Parkin-expressing U2OS cells were treated with the depolari...

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Identifiers and source

Literature Corpus work: cf688bcb-46d1-50a3-9407-ffd51c7520ed
DOI: 10.1101/2025.03.24.645001

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