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Microglial metabolic reprogramming drives cognitive decline in heart failure with preserved ejection fraction

2025-09-16

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is a rapidly growing public health concern and an emerging contributor to dementia, yet the mechanisms linking cardiometabolic dysfunction to neurodegeneration remain poorly understood. Here, we demonstrate that HFpEF drives a sustained neuroinflammatory state through microglial metabolic reprogramming. Using a clinically relevant murine model of HFpEF, we ide...

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Identifiers and source

Literature Corpus work
f1889582-16df-598c-a325-acfdee92a5d5
DOI
10.1101/2025.09.10.675257
Open publication

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Microglial metabolic reprogramming drives cognitive decline in heart failure with preserved ejection fractionDOI 10.1101/2025.09.10.675257
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