Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage-Dependent Intercellular Crosstalk in Multiphenotypic Heart Failure With Preserved Ejection Fraction.

Journal of the American Heart Association - 7 Jul 2026

Huang Yangyang, Luo Lingyun, Ma Xiantao, Huang Yajuan, Zhang Chen, Hao Xingjie, Zhang Le, Zhu Hongling, Dai Lei, Liu Min

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is now recognized as a complex, multiphenotypic metabolic syndrome fueled by inflammation and metabolic dysregulation, rather than a single disease entity. Cardiac macrophages, as the most abundant immune cells in the heart, are emerging as central players in HFpEF pathogenesis by orchestrating intercellular crosstalk and driving maladaptive remodeling. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Communication
Share to Heart Failure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Myocytes, Cardiac

Share to Phenotype

Share to Stroke Volume

Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 42333684
DOI: 10.1161/JAHA.125.047429
PMCID: PMC13477383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage-Dependent Intercellular Crosstalk in Multiphenotypic Heart Failure With Preserved Ejection Fraction.PMID 42333684Read ↗

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment.Semantic proximity Read ↗

Cardiac macrophages in maintaining heart homeostasis and regulating ventricular remodeling of heart diseases.Semantic proximity Read ↗

Functional diversity of cardiac macrophages in health and diseaseSemantic proximity Read ↗

Macrophages and fibroblasts in cardiac fibrosis: interactions and transformationSemantic proximity Read ↗

The human heart contains distinct macrophage subsets with divergent origins and functionsSemantic proximity Read ↗

Cellular cross-talks in the diseased and aging heartSemantic proximity Read ↗

The role of cardiac resident macrophage in cardiac agingSemantic proximity Read ↗

Dissecting and Visualizing the Functional Diversity of Cardiac MacrophagesSemantic proximity Read ↗

Distinct origins and functions of cardiac orthotopic macrophages.Semantic proximity Read ↗

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic DysfunctionSemantic proximity Read ↗

Resident cardiac macrophages: Heterogeneity and function in health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.