Article

Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging

2023-11-30

Abstract excerpt

Despite Alzheimer’s disease (AD) disproportionately affecting women, the mechanisms remain elusive. In AD, microglia undergo ‘metabolic reprogramming’, which contributes to microglial dysfunction and AD pathology. However, how sex and age contribute to metabolic reprogramming in microglia is understudied. Here, we use metabolic imaging, transcriptomics, and metabolic assays to probe age-and sex-associated changes...

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Literature Corpus work: 373d110e-636d-56fe-99e6-fb32b4a269c8
DOI: 10.1101/2023.11.28.569104

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