Article

Glioblastoma Invasion Remodels Neural Circuits and Drives Persistent GABAergic Dysfunction in Human Brain Organoids

2026-08-12

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM) is characterized by neurological dysfunction caused by tumor cells that interact with and alter neuronal circuits. However, the specific neuronal populations and molecular mechanisms most susceptible to GBM invasion remain poorly understood. <h4>Methods</h4> We created a human tumor–brain organoid model by combining U87 glioblastoma cells with iPSC-derived neural organoids....

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Literature Corpus work: f15f664f-c32e-5cf1-936c-d10843a30d8d
DOI: 10.64898/2026.08.11.744022

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