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The multilayered transcriptional architecture of glioblastoma ecosystems

1 May 2025

Abstract excerpt

In isocitrate dehydrogenase wildtype glioblastoma (GBM), cellular heterogeneity across and within tumors may drive therapeutic resistance. Here we analyzed 121 primary and recurrent GBM samples from 59 patients using single-nucleus RNA sequencing and bulk tumor DNA sequencing to characterize GBM transcriptional heterogeneity. First, GBMs can be classified by their broad cellular composition, encompassing...

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PMID: 40346361
DOI: 10.1038/s41588-025-02167-5

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