Article

Iron-Associated Mesenchymal Plasticity and Tumor Invasion in Glioblastoma

2025-12-24

Abstract excerpt

Glioblastoma (GBM) recurrence is driven by tumor cells that infiltrate surrounding brain tissue and evade surgical and therapeutic eradication. Although dysregulated iron handling is a recognized feature of the necrotic and hemorrhagic GBM tumor core, its relationship to invasive tumor cell states remains incompletely defined. Here, we investigated how iron-associated microenvironments relate to transcriptional pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dfb484f2-c9c1-5978-987a-b652aaeee513
DOI: 10.64898/2025.12.22.695920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Iron-Associated Mesenchymal Plasticity and Tumor Invasion in GlioblastomaDOI 10.64898/2025.12.22.695920Read

Spatially Integrated Multi-Omics reveals the Multicellular Landscape of Progenitor-Driven Glioblastoma ProgressionSemantic proximity Read

Tissue-reactive zonation of mesenchymal-like phenotypes in human glioblastoma.Semantic proximity Read

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human GlioblastomaSemantic proximity Read

Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactionsSemantic proximity Read

Local Tumor Microenvironment Niches Correlate With Survival And Immunotherapy Response In Human GlioblastomaSemantic proximity Read

Single-cell and spatial transcriptomic profiling of primary versus recurrent glioblastoma identifies PLOD2 as a core orchestrator of hypoxic niche remodeling and mesenchymal transitionSemantic proximity Read

Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell linesSemantic proximity Read

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical nichesSemantic proximity Read

Glioblastoma Invasion Remodels Neural Circuits and Drives Persistent GABAergic Dysfunction in Human Brain OrganoidsSemantic proximity Read

Molecular and cellular intratumoral heterogeneity in primary glioblastoma: clinical and translational implicationsSemantic proximity Read

Iron Inhibits Glioblastoma Cell Migration and PolarizationSemantic proximity Read

Identification of an epigenetically and phenotypically distinct peritumoral glioblastoma cell population linked to inferior patient outcomeSemantic proximity Read