Article

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

2019-05-07

Abstract excerpt

Glioblastoma multiforme (GBM) are devastating neoplasms with high invasive capacity. GBM has been difficult to study in vitro . Therapeutic progress is also limited by cellular heterogeneity within and between tumors. To address these challenges, we present an experimental model using human cerebral organoids as a scaffold for patient-derived glioblastoma cell invasion. By tissue clearing and confocal microscopy,...

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Literature Corpus work: 956f5908-b1b3-5422-a9ac-50c705e0a5f4
DOI: 10.1101/630202

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