Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs

25 Jan 2024

Abstract excerpt

Recent advances in the genomics of glioblastoma (GBM) led to the introduction of molecular neuropathology but failed to translate into treatment improvement. This is largely attributed to the genetic and phenotypic heterogeneity of GBM, which are considered the major obstacle to GBM therapy. Here, we use advanced human GBM-like organoid (LEGO: Laboratory Engineered Glioblastoma-like Organoid) models and provide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Glioma Diagnosis and Treatment
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38273014
DOI: 10.1038/s41698-024-00500-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugsPMID 38273014Read ↗

A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugsSemantic proximity Read ↗

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read ↗

Multi-omics and pharmacological characterization of patient-derived glioma cell linesSemantic proximity Read ↗

Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivitySemantic proximity Read ↗

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomasSemantic proximity Read ↗

Glioblastoma Invasion Remodels Neural Circuits and Drives Persistent GABAergic Dysfunction in Human Brain OrganoidsSemantic proximity Read ↗

Advancing glioblastoma treatment by targeting metabolismSemantic proximity Read ↗

Proteogenomic and metabolomic characterization of human glioblastoma.Semantic proximity Read ↗

Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based ApproachSemantic proximity Read ↗

A Propionate Metabolism-Based Gene Signature Reveals Immunogenomic and Transcriptomic Determinants of Prognosis in Glioblastoma Through Multiomics Integration.Semantic proximity Read ↗

Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma ProgressionSemantic proximity Read ↗

Integrating Multi-Omics Analysis for Enhanced Diagnosis and Treatment of Glioblastoma: A Comprehensive Data-Driven ApproachSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.