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Article

Tissue-reactive zonation of mesenchymal-like phenotypes in human glioblastoma.

Med (New York, N.Y.) - 14 Aug 2026

Mossi Albiach Alejandro, Janusauskas Jokubas, Kjaer Jacobsen Jesper, Kapustová Ivana, Karamzadeh Razieh, Kvedaraite Egle, Hu Lijuan, Franck Marina C M, Ramal García Maria, Fernández-García David, Mannens Camiel, Codeluppi Simone, Munting Johannes B, Borm Lars E, Shamikh Alia, Lönnerberg Peter, Siletti Kimberly, Persson Oscar, Linnarsson Sten

Abstract excerpt

BACKGROUND: Glioblastoma is the deadliest brain cancer, characterized by large cellular diversity. Both neurodevelopment-like and mesenchymal-like cell states have been described, with the latter being strongly implicated in malignancy and disease progression. However, the spatial organization of these mesenchymal-like cell states has not been systematically described outside the tumor bulk. METHODS: We performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42492522
DOI: 10.1016/j.medj.2026.101228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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