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Conservation of single amino-acid polymorphisms in <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 and association with severe pathophysiology

2017-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a parasite protein encoded by a multigene family known as var. Expressed on the surface of infected red blood cells, PfEMP1 plays a central role in parasite virulence. The DBLα domain of PfEMP1 contains short sequence motifs termed homology blocks. Variation within homology blocks, at the level of single amino-acid modificatio...

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Literature Corpus work
3b361eb9-6f69-5bf6-b157-1e9f4748af96
DOI
10.1101/128983
Open publication

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Conservation of single amino-acid polymorphisms in <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 and association with severe pathophysiologyDOI 10.1101/128983
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