Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics.

doi:10.1016/j.ajhg.2023.09.012

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Article

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics.

American journal of human genetics - 2 Nov 2023

Chan Tsz Fung, Rui Xinyue, Conti David V, Fornage Myriam, Graff Mariaelisa, Haessler Jeffrey, Haiman Christopher, Highland Heather M, Jung Su Yon, Kenny Eimear E, Kooperberg Charles, Le Marchand Loic, North Kari E, Tao Ran, Wojcik Genevieve, Gignoux Christopher R, Chiang Charleston W K, Mancuso Nicholas

Abstract excerpt

The heritability explained by local ancestry markers in an admixed population (hγ2) provides crucial insight into the genetic architecture of a complex disease or trait. Estimation of hγ2 can be susceptible to biases due to population structure in ancestral populations. Here, we present heritability estimation from admixture mapping summary statistics (HAMSTA), an approach that uses summary statistics from...

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PMID: 37875120
DOI: 10.1016/j.ajhg.2023.09.012
PMCID: PMC10645552

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