Article

Accelerated amyloid neurodegeneration in HIV-1-infected APP-KI Alzheimer’s disease mice

2026-05-19

Abstract excerpt

<h4>STRUCTURED ABSTRACT</h4> <h4>INTRODUCTION</h4> A higher incidence of dementia, including Alzheimer ’s-like pathology, is observed in aged people living with HIV-1. However, mechanisms linking HIV-1 to Alzheimer’s disease (AD) pathology remain unclear, due to the lack of animal models that allow for concurrent study. <h4>METHODS</h4> We created a novel APP knock-in (KI) AD mouse, NOG/APP KM670,671NL /IL-34...

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Literature Corpus work: f126daa0-abc6-50d8-b604-8da677919852
DOI: 10.64898/2026.05.16.725620

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