Article

HIV-1 Infection in Humanized Microglial Mice Disrupts Feeding Behavior and Circadian Rhythms with Cortical Neuroinflammation

2026-07-01

Abstract excerpt

Although effective antiretroviral therapy (ART) has substantially reduced the severity of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND), the condition remains highly prevalent. Understanding HAND has been a challenge due to the lack of small animal models capable of supporting productive HIV infection in the brain. Recent advances in humanized mouse models with engrafted human glial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ec5a0c8-fd26-5ba5-84a0-88f80f93739b
DOI: 10.64898/2026.06.25.733229

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Infection in Humanized Microglial Mice Disrupts Feeding Behavior and Circadian Rhythms with Cortical NeuroinflammationDOI 10.64898/2026.06.25.733229Read

Novel method to quantify phenotypic markers of HIV-associated neurocognitive disorder in a murine SCID model.Semantic proximity Read

A novel glia-immune humanized mouse model for investigating neuroimmune mechanisms in CNS HIV infection and diverse neurological disordersSemantic proximity Read

Neurological impact of HIV/AIDS and substance use alters brain function and structureSemantic proximity Read

Accelerated amyloid neurodegeneration in HIV-1-infected APP-KI Alzheimer’s disease miceSemantic proximity Read

Genomic Factors and Therapeutic Approaches in HIV-Associated Neurocognitive Disorders: A Comprehensive ReviewSemantic proximity Read

Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain RegionsSemantic proximity Read

NLRP3 inflammasome-related microglial pyroptosis in EcoHIV infected miceSemantic proximity Read

Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated AgingSemantic proximity Read

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse modelSemantic proximity Read

Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory ResponsesSemantic proximity Read

Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disordersSemantic proximity Read

HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)Semantic proximity Read