Article
Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025
Yeapuri Pravin, Machhi Jatin, Foster Emma G, Kadry Rana, Bhattarai Shaurav, Lu Yaman, Sil Susmita, Sapkota Roshan, Srivastava Shefali, Kumar Mohit, Ikezu Tsuneya, Poluektova Larisa Y, Gendelman Howard E, Mosley Rodney Lee
Abstract excerpt
INTRODUCTION: Transgenic mice overexpressing familial Alzheimer's disease (AD) mutations (FAD) show non-physiological traits, and their immunocompetent backgrounds limit their use in AD immunotherapy research. Preclinical models that reflect human immune responses in AD are needed. METHODS: Using...
Topics
- Animals
- Amyloid beta-Protein Precursor
- Presenilin-1
- Mice, Transgenic
- Mice
- Disease Models, Animal
- Alzheimer Disease
- Gene Knock-In Techniques
- Neurons
- Humans