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The association between transcriptional regulation of macrophage differentiation and activation and genetic susceptibility to inflammatory bowel disease

2022-12-15

Abstract excerpt

The abundant macrophage population of the intestinal lamina propria turns over rapidly and is replaced by blood monocytes. The differentiation and survival of resident intestinal macrophages depends upon signals from the macrophage colony-stimulating factor receptor (CSF1R). The response of human monocyte-derived macrophages (MDM) grown in macrophage colony-stimulating factor (CSF1) to bacterial lipopolysaccharide...

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Literature Corpus work
f11b2188-61ac-57c6-9699-ab0682fc3aa9
DOI
10.1101/2022.12.14.520373
Open publication

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