Article
Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.
Nature communications - 20 Oct 2014
Kim Sarah, Becker Jessica, Bechheim Matthias, Kaiser Vera, Noursadeghi Mahdad, Fricker Nadine, Beier Esther, Klaschik Sven, Boor Peter, Hess Timo, Hofmann Andrea, Holdenrieder Stefan, Wendland Jens R, Fröhlich Holger, Hartmann Gunther, Nöthen Markus M, Müller-Myhsok Bertram, Pütz Benno, Hornung Veit, Schumacher Johannes
Abstract excerpt
Toll-like receptors (TLRs) play a key role in innate immunity. Apart from their function in host defense, dysregulation in TLR signalling can confer risk to autoimmune diseases, septic shock or cancer. Here we report genetic variants and transcripts that are active only during TLR signalling and contribute to interindividual differences in immune response. Comparing unstimulated versus TLR4-stimulated monocytes...
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