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Article

IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation.

Science immunology - 22 May 2020

Corbin Alastair L, Gomez-Vazquez Maria, Berthold Dorothée L, Attar Moustafa, Arnold Isabelle C, Powrie Fiona M, Sansom Stephen N, Udalova Irina A

Abstract excerpt

Mononuclear phagocytes (MNPs) are vital for maintaining intestinal homeostasis but, in response to acute microbial stimulation, can also trigger immunopathology, accelerating recruitment of Ly6Chi monocytes to the gut. The regulators that control monocyte tissue adaptation in the gut remain poorly understood. Interferon regulatory factor 5 (IRF5) is a transcription factor previously shown to play a key role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32444476
DOI: 10.1126/sciimmunol.aax6085
PMCID: PMC7611075

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