Article

IRF5 promotes intestinal inflammation by guiding monocyte differentiation towards a pathogenic CD11c <sup>+</sup> macrophage phenotype

2019-04-07

Abstract excerpt

Mononuclear phagocytes (MNPs) play a key role in maintaining intestinal homeostasis but also in triggering immunopathology in response to acute microbial stimulation, which induces the recruitment of masses of Ly6C hi monocytes to the gut. The regulators that control monocyte tissue adaptation in the gut remain poorly understood. Interferon Regulatory Factor 5 (IRF5) is a transcription factor previously shown to...

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Literature Corpus work: 44db9895-907b-5de7-adeb-58928a68a9d1
DOI: 10.1101/601963

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