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Article

A broken network of susceptibility genes in the monocytes of Crohn's disease patients.

Life science alliance - 1 Sept 2024

Liu Hankui, Guan Liping, Su Xi, Zhao Lijian, Shu Qing, Zhang Jianguo

Abstract excerpt

Genome-wide association studies have identified over 200 genetic loci associated with inflammatory bowel disease; however, the mechanism of such a large amount of susceptibility genes remains uncertain. In this study, we integrated bioinformatics analysis and two independent single-cell transcriptome datasets to investigate the expression network of 232 susceptibility genes in Crohn's disease (CD) patients and...

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Identifiers

PMID: 38925865
DOI: 10.26508/lsa.202302394
PMCID: PMC11208737

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