Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.
PLoS genetics - 1 Mar 2017
Baillie J Kenneth, Arner Erik, Daub Carsten, De Hoon Michiel, Itoh Masayoshi, Kawaji Hideya, Lassmann Timo, Carninci Piero, Forrest Alistair R R, Hayashizaki Yoshihide, Faulkner Geoffrey J, Wells Christine A, Rehli Michael, Pavli Paul, Summers Kim M, Hume David A
Abstract excerpt
The FANTOM5 consortium utilised cap analysis of gene expression (CAGE) to provide an unprecedented insight into transcriptional regulation in human cells and tissues. In the current study, we have used CAGE-based transcriptional profiling on an extended dense time course of the response of human monocyte-derived macrophages grown in macrophage colony-stimulating factor (CSF1) to bacterial lipopolysaccharide...
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