Oncogenic Role of Aberrant EZH2 in Hepatoblastoma

Abstract excerpt

<h4>ABSTRACT</h4> Hepatoblastoma (HB) is the most common pediatric liver malignancy. However, its cellular origin and molecular drivers remain poorly defined. Using single-nuclear RNA sequencing (snRNA-seq), we identified a proliferative, hepatocyte-derived tumor cell population (cycling Hep T ) enriched for Enhancer of Zeste Homolog 2 ( EZH2) expression, particularly in the aggressive embryonal subtype. Integr...

Topics

Open a Topic to create a Post that cites this publication.

• Drug Resistance, Neoplasm
• Enhancer of Zeste Homolog 2 Protein
• Epigenetics and DNA Methylation
• Gene Expression Regulation, Neoplastic
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Signal Transduction

Identifiers and source

Literature Corpus work

bc47f62c-fcd4-53d0-a854-c48554b7f048

DOI

10.1101/2025.07.30.667506