Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.

Cell reports - 7 Mar 2017

Mobley Robert J, Raghu Deepthi, Duke Lauren D, Abell-Hart Kayley, Zawistowski Jon S, Lutz Kyla, Gomez Shawn M, Roy Sujoy, Homayouni Ramin, Johnson Gary L, Abell Amy N

Abstract excerpt

The first epithelial-to-mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TSKI4 cells) induces an intermediate state of EMT, where cells retain stemness, lose epithelial markers, and gain mesenchymal characteristics. Investigation of relationships among MAP3K4 activity, stemness, and EMT in TS cells may reveal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Epithelial-Mesenchymal Transition

Share to Proteolysis

Share to Stem Cells

Share to Trophoblasts

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 28273454
DOI: 10.1016/j.celrep.2017.02.030
PMCID: PMC5496714

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.PMID 28273454Read ↗

MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells.Semantic proximity Read ↗

Dynamic and distinct histone modifications facilitate human trophoblast lineage differentiationSemantic proximity Read ↗

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.Semantic proximity Read ↗

SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and BlastoidsSemantic proximity Read ↗

MYPT1/PP1‐Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial–Mesenchymal Transition in Fibrosis through Control of Multiple Families of GenesSemantic proximity Read ↗

Molecular determinants of epithelial mesenchymal transition in mouse placenta and trophoblast stem cellSemantic proximity Read ↗

The Epigenetic Factor PHF13 Governs Trophoblast Stemness and DifferentiationSemantic proximity Read ↗

KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2Semantic proximity Read ↗

TGFb-induced SMAD1/5 activation drives transient epithelial-to-mesenchymal transition in trophoblastsSemantic proximity Read ↗

Elevated histone demethylase KDM5C increases recurrent miscarriage risk by preventing trophoblast proliferation and invasionSemantic proximity Read ↗

Essential roles of Hdac1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation developmentSemantic proximity Read ↗

SALL2 constrains TEAD4 by maintaining repressive chromatin to restrict trophectoderm identitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.