Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer.

doi:10.1186/s12885-015-1889-2

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Article

Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer.

BMC cancer - 9 Nov 2015

Fornaro Lorenzo, Faviana Pinuccia, De Gregorio Veronica, Vivaldi Caterina, Paolicchi Elisa, Masi Gianluca, Loupakis Fotios, Sensi Elisa, Lupi Cristiana, Fontanini Gabriella, Wang Yuzhuo, Danesi Romano, Falcone Alfredo, Crea Francesco

Abstract excerpt

BACKGROUND: The enhancer of zeste-homolog 2 (EZH2) is involved in cancer development through gene silencing by trimethylation of lysine 27 of histone 3 (H3K27me3). The C/C genotype for the EZH2 rs3757441 single-nucleotide polymorphism (SNP) is linked with poor prognosis in metastatic colorectal cancer (CRC), but molecular and pathological characterization of this SNP is lacking. METHODS: 119 primary CRCs were...

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PMID: 26553291
DOI: 10.1186/s12885-015-1889-2
PMCID: PMC4640238

Genes

BRAF
KRAS

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