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Article

Sex-Specific Features of Microglia from Adult Mice.

Cell reports - 19 Jun 2018

Villa Alessandro, Gelosa Paolo, Castiglioni Laura, Cimino Mauro, Rizzi Nicoletta, Pepe Giovanna, Lolli Federica, Marcello Elena, Sironi Luigi, Vegeto Elisabetta, Maggi Adriana

Abstract excerpt

Sex has a role in the incidence and outcome of neurological illnesses, also influencing the response to treatments. Neuroinflammation is involved in the onset and progression of several neurological diseases, and the fact that estrogens have anti-inflammatory activity suggests that these hormones may be a determinant in the sex-dependent manifestation of brain pathologies. We describe significant differences in...

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Identifiers

PMID: 29924994
DOI: 10.1016/j.celrep.2018.05.048
PMCID: PMC6024879

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