Article
Early-Life Systemic Inflammation Modulate Microglia Phenotype to Slow Down Aβ Pathology in the 5xFAD Mouse Model of Alzheimer’s Disease
2024-11-19
Abstract excerpt
<h4>Summary</h4> Early infection in life has been implicated in increasing the risk for neurological disorders. Here we performed single-cell sequencing of microglia and monocytes from 6-month-old WT and 5xFAD mice subjected to one dose of LPS (1mg/kg) at postnatal day 9. We successfully mapped disease-associated microglia (DAM) and perivascular macrophages in our data and demonstrated a subpopulation of microgli...
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Identifiers and source
- Literature Corpus work
- 8a722b2a-a771-5240-a8ff-9066f8b6ff4a
- DOI
- 10.1101/2024.11.19.624204