Synthetic lethality in large-scale integrated metabolic and regulatory network models of human cells

Abstract excerpt

Synthetic lethality (SL) is a promising concept in cancer research. A wide array of computational tools has been developed to predict and exploit synthetic lethality for the identification of tumour-specific vulnerabilities. Previously, we introduced the concept of genetic Minimal Cut Sets (gMCSs), a theoretical approach to SL for genome-scale metabolic networks. The major challenge in our gMCS framework is to go...

Topics

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• Bioinformatics and Genomic Networks
• Cell Proliferation
• Computational Drug Discovery Methods
• Gene Expression
• Health Status
• Neoplasms
• Phenotype
• Systems Biology

Identifiers and source

Literature Corpus work

53e71e3d-e66c-5edd-8cf5-d5819f1eef6c

DOI

10.1101/2023.01.27.525829