Article

Understanding flux switching in metabolic networks through an analysis of synthetic lethals

2024-03-09

Abstract excerpt

Biological systems are extremely robust and exhibit high levels of redundancy for multiple cellular functions. Some of this redundancy manifests as alternative pathways in metabolism. Synthetic double lethals in metabolic networks comprise pairs of reactions, which, when deleted simultaneously, abrogate cell growth. However, when one reaction from such pairs is removed, the cell reroutes its metabolites through al...

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Literature Corpus work: d3dc320b-4544-5db4-8146-363eba721456
DOI: 10.1101/2024.03.05.583461

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