Article

CASTLE: A database of synthetic lethal sets predicted from genome-scale metabolic networks

2021-02-08

Abstract excerpt

<h4>Summary</h4> Genome-scale metabolic networks have been reconstructed for hundreds of organisms over the last two decades, with wide-ranging applications, including the identification of drug targets. Constraint-based approaches such as flux balance analysis have been effectively used to predict single and combinatorial drug targets in a variety of metabolic networks. We have previously developed Fast-SL, an e...

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Literature Corpus work: eb1380b8-da7e-5184-80ed-caf443ef417b
DOI: 10.1101/2021.02.08.430024

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