Article

Adding metabolic tasks to Human GEM models to improve the study of gene targets and their associated toxicities

2024-05-21

Abstract excerpt

<title>Abstract</title> <p>Genetic minimal cut sets (gMCS) are sets of genes that must be deactivated simultaneously to avoid unwanted states in a metabolic model. The concept of gMCS can be applied to two different scenarios. First, it can be used to identify potential gene toxicities in generic or healthy cell models. Second, it can be used to develop genetic strategies to target cancer cells and prevent their...

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Literature Corpus work: 14a2a1d4-e156-542c-8c9d-1001c7805f4c
DOI: 10.21203/rs.3.rs-4311169/v1

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