Article

p53 Transactivation Domain Mediates Binding and Phase Separation With poly-PR/GR

2021-09-15

Abstract excerpt

Abstract: The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR dipeptide repeats which are encoded by the C9orf72 gene. Recently, it was shown that poly-PR/GR alters chromatin accessibility which results in stabilization and enhancement of transcriptional activity of the tumor suppressor p53 in several neurodegenerative disease models....

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Literature Corpus work: f0a7a5e2-e1ba-575f-9ed6-5142609fa8ff
DOI: 10.20944/preprints202109.0265.v1

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