Article

Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by photoinducible platform

2021-02-15

Abstract excerpt

<title>Abstract</title> <p>Dipeptide repeats (DPRs) translated from the mutated <italic>C9orf72</italic> gene have recently been correlated with amyotrophic lateral sclerosis (ALS). Within these DPRs, the most abundant glycine-alanine (GA) DPRs form insoluble inclusions in <italic>C9orf72</italic>-ALS patients. While GA DPRs aggregates have been considered as amyloid, the biophysical features and cytotoxicity of...

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Literature Corpus work: 702be99d-c82c-5a67-8702-69eb6c92fb26
DOI: 10.21203/rs.3.rs-209180/v1

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