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Article

Dipeptide repeat derived from C9orf72 hexanucleotide expansions forms amyloids or natively unfolded structures in vitro.

Biochemical and biophysical research communications - 28 May 2020

Brasseur Laurent, Coens Audrey, Waeytens Jehan, Melki Ronald, Bousset Luc

Abstract excerpt

The abnormal repetition of the hexanucleotide GGGGCC within the C9orf72 gene is the most common genetic cause of both Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Different hypothesis have been proposed to explain the pathogenicity of this mutation. Among them, the production of aberrant proteins called Dipeptide Repeat Proteins (DPR) from the repeated sequence. Those proteins are of...

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Amyloid
Amyotrophic Lateral Sclerosis
C9orf72 Protein
Dipeptides
Frontotemporal Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotides

Protein Unfolding

Repetitive Sequences, Nucleic Acid

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PMID: 32223927
DOI: 10.1016/j.bbrc.2020.03.108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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