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Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

1 Jun 2017

Abstract excerpt

Recent data have expanded our understanding of Notch signalling by identifying a C2 domain at the N-terminus of Notch ligands, which has both lipid- and receptor-binding properties. We present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in...

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PMID: 28572448
DOI: 10.15252/embj.201796632

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