Article

Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disorders

2022-05-21

Abstract excerpt

Exposure to stressful events increases risk for psychiatric disorders. Mechanistic insight into genetic factors moderating the impact of stress can increase our understanding of disease processes. Here, we test 3662 SNPs from preselected expression quantitative trait loci in massively parallel reporter assays to identify genetic variants that modulate the activity of regulatory elements sensitive to glucocorticoid...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f08ae458-f441-56b3-869f-51997e0f6aa8
DOI: 10.1101/2022.05.18.22275090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Assessment of glucocorticoid-induced enhancer activity of eSNP regions using STARR-seq reveals novel molecular mechanisms in psychiatric disordersDOI 10.1101/2022.05.18.22275090Read

High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders.Semantic proximity Read

Multi-omics analysis of the molecular response to glucocorticoids - insights into shared genetic risk from psychiatric to medical disordersSemantic proximity Read

Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common DiseasesSemantic proximity Read

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.Semantic proximity Read

Common genetic variation impacts stress response in the brainSemantic proximity Read

A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depressionSemantic proximity Read

Gene × Environment Determinants of Stress- and Anxiety-Related Disorders.Semantic proximity Read

A genomic study of the Japanese population focusing on the glucocorticoid receptor interactome highlights distinct genetic characteristics associated with stress responseSemantic proximity Read

Dynamic regulation of glucocorticoid signalling in health and diseaseSemantic proximity Read

A Genomic Study of the Japanese Population Focusing on the Glucocorticoid Receptor Interactome Highlights Distinct Genetic Characteristics Associated with Stress Response.Semantic proximity Read

Genome-wide Association Study of Anxiety and Stress-related Disorders in the iPSYCH CohortSemantic proximity Read

Genetics of stress response and stress-related disordersSemantic proximity Read