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Article

Functional polygenic risk score of glucocorticoid-dependent regulatory element activity and its relation to clinical and stress-related phenotypes.

Psychoneuroendocrinology - 1 Feb 2026

Linsen F, Habets P C, Milaneschi Y, Penner-Goeke S, Mishuris B, Czamara D, Penninx B W J H, Binder E B, Meijer O C, Vinkers C H

Abstract excerpt

BACKGROUND: Chronic stress and adverse life events are major contributors to depression and anxiety disorders. Genetic variants that influence glucocorticoid (GC) hormone responses may moderate the impact of stress on psychiatric outcomes. Here, we use a functional polygenic risk score (fPRS) based on GC-responsive gene regulatory elements (GREs) following dexamethasone (DEX) exposure (DEX-fPRS) and examined its...

Read the complete abstract on PubMed

Topics

Humans
Male
Female
Glucocorticoids
Adult
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Dexamethasone

Stress, Psychological

Phenotype

Hydrocortisone

Multifactorial Inheritance

Anxiety Disorders

Cohort Studies

Depression

Netherlands

Saliva

Risk Factors

Genetic Predisposition to Disease

Source

Identifiers

PMID: 41319386
DOI: 10.1016/j.psyneuen.2025.107703

Genes

GC

Provenance

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