Article
High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders.
Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2023
Penner-Goeke Signe, Bothe Melissa, Rek Nils, Kreitmaier Peter, Pöhlchen Dorothee, Kühnel Anne, Glaser Laura V, Kaya Ezgi, Krontira Anthi C, Röh Simone, Czamara Darina, Ködel Maik, Monteserin-Garcia Jose, Diener Laura, Wölfel Barbara, Sauer Susann, Rummel Christine, Riesenberg Stephan, Arloth-Knauer Janine, Ziller Michael, Labeur Marta, Meijsing Sebastiaan, Binder Elisabeth B
Abstract excerpt
Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic insight into the genetic factors moderating the impact of stress can increase our understanding of disease processes. Here, we test 3,662 single nucleotide polymorphisms (SNPs) from preselected expression quantitative trait loci in massively parallel reporter assays to identify genetic variants that modulate the activity...
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