Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.

doi:10.1016/j.neuron.2015.05.034

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Article

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.

Neuron - 3 Jun 2015

Arloth Janine, Bogdan Ryan, Weber Peter, Frishman Goar, Menke Andreas, Wagner Klaus V, Balsevich Georgia, Schmidt Mathias V, Karbalai Nazanin, Czamara Darina, Altmann Andre, Trümbach Dietrich, Wurst Wolfgang, Mehta Divya, Uhr Manfred, Klengel Torsten, Erhardt Angelika, Carey Caitlin E, Conley Emily Drabant, Ruepp Andreas, Müller-Myhsok Bertram, Hariri Ahmad R, Binder Elisabeth B

Abstract excerpt

Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mechanisms through which these factors interact to confer depression risk are poorly understood. One putative biological mechanism implicates variability in the ability of cortisol, released in response to stress, to trigger a cascade of adaptive genomic and non-genomic processes through glucocorticoid receptor (GR)...

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PMID: 26050039
DOI: 10.1016/j.neuron.2015.05.034
PMCID: PMC4490780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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