Article

A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring

2025-05-31

Abstract excerpt

<h4>Abstract Summary</h4> Chordoid glioma (ChG) is a rare, low-grade brain tumor characterized by a novel recurrent point mutation, D463H, in the kinase domain of protein kinase C alpha (PKCα). The mutation is invariably an Asp to His substitution, suggesting it endows a unique function beyond catalytic inactivation associated with other cancer-associated PKCα mutations. Here we use in vitro and in cellulo acti...

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Literature Corpus work: f06e7a75-e2f8-54d1-a64b-671b8e5ee46e
DOI: 10.1101/2025.05.30.657104

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