Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Equivocal, explicit and emergent actions of PKC isoforms in cancer.

Nature reviews. Cancer - 1 Jan 2021

Parker Peter J, Brown Sophie J, Calleja Veronique, Chakravarty Probir, Cobbaut Mathias, Linch Mark, Marshall Jacqueline J T, Martini Silvia, McDonald Neil Q, Soliman Tanya, Watson Lisa

Abstract excerpt

The maturing mutational landscape of cancer genomes, the development and application of clinical interventions and evolving insights into tumour-associated functions reveal unexpected features of the protein kinase C (PKC) family of serine/threonine protein kinases. These advances include recent work showing gain or loss-of-function mutations relating to driver or bystander roles, how conformational constraints...

Topics

Join the communities discussing this publication.

Isoenzymes
Mutation
Neoplasms
Phosphorylation
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase C

Tumor Microenvironment

Source

Identifiers

PMID: 33177705
DOI: 10.1038/s41568-020-00310-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Equivocal, explicit and emergent actions of PKC isoforms in cancer.PMID 33177705Read ↗

Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune ResponseSemantic proximity Read ↗

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.Semantic proximity Read ↗

Protein kinase C as a tumor suppressor.Semantic proximity Read ↗

The PKC universe keeps expanding: From cancer initiation to metastasis.Semantic proximity Read ↗

The complexities of PKCα signaling in cancer.Semantic proximity Read ↗

DNA-PKcs: A Targetable Protumorigenic Protein KinaseSemantic proximity Read ↗

The Emerging Function of PKCtheta in CancerSemantic proximity Read ↗

Pan-Cancer Study on Protein Kinase C Family as a Potential Biomarker for the Tumors Immune Landscape and the Response to ImmunotherapySemantic proximity Read ↗

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interfaceSemantic proximity Read ↗

Cancer-associated mutations in protein kinase C theta are loss-of-function.Semantic proximity Read ↗

Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma.Semantic proximity Read ↗

PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.