Article
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.
Cell - 29 Jan 2015
Antal Corina E, Hudson Andrew M, Kang Emily, Zanca Ciro, Wirth Christopher, Stephenson Natalie L, Trotter Eleanor W, Gallegos Lisa L, Miller Crispin J, Furnari Frank B, Hunter Tony, Brognard John, Newton Alexandra C
Abstract excerpt
Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations identified in human cancers and found that, surprisingly, most were loss of function and none were activating. Loss-of-function mutations occurred in all PKC subgroups and impeded...
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