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Article

Cancer-associated mutations in protein kinase C theta are loss-of-function.

The Biochemical journal - 19 Jun 2024

Hodapp Stefanie J, Gravel Nathan, Kannan Natarajan, Newton Alexandra C

Abstract excerpt

The Ca2+-independent, but diacylglycerol-regulated, novel protein kinase C (PKC) theta (θ) is highly expressed in hematopoietic cells where it participates in immune signaling and platelet function. Mounting evidence suggests that PKCθ may be involved in cancer, particularly blood cancers, breast cancer, and gastrointestinal stromal tumors, yet how to target this kinase (as an oncogene or as a tumor suppressor)...

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Identifiers

PMID: 38752473
DOI: 10.1042/BCJ20240148
PMCID: PMC11346454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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