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Article

Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors.

The EMBO journal - 1 Dec 2025

Boni Jacopo, Fernández-González Míriam, Han HyeRim, Roca Carla, Wong Cassandra J, Rioja Cristina, Nogué Clara, Manen-Freixa Leticia, Boulais Jonathan, Torres-Urtizberea Endika, Gomez Antonio, Hasselblatt Martin, Estrada-Tejedor Roger, Antolin Albert A, Elkholi Islam E, Jabado Nada, Côté Jean-François, Gingras Anne-Claude, Rivera Barbara

Abstract excerpt

FGFR1 genetic alterations are associated with brain malignancies, including FGFR1 mutations in familial and sporadic cases of low-grade glioneuronal tumors, suggesting intrinsic mechanisms of selective pressure toward FGFR1 multiple events arising in the context of a quiet genome. To decipher the molecular mechanisms triggered by multiple concurrent FGFR1 mutations, we have mapped the proximal interactome of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Identifiers

PMID: 41174249
DOI: 10.1038/s44318-025-00600-3
PMCID: PMC12705663

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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